Professor Milo
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History
A renowned chemistry|chemist who turned to crime, he used a variety of chemical and medical-related schemes to kill Batman involving subjecting Batman to a drug that made him afraid of anything bat-shaped, gassing Batman with a compound that made him lose his will to live, manipulating the werewolf-like Anthony Lupus into doing his bidding, taking control of Arkham Asylum, and attempting to make Batman insane with yet another gas. He was later exposed to chemicals that drove him insanity|insane, and he spent some time in Arkham Asylum. Batman consulted him on at least one occasion when he needed chemical expertise given to him by The Joker. After that, Dr. Milo retired from criminal activity. He appeared in Arkham Asylum: A Serious House on Serious Earth, where the gas had apparently worn off, but he couldn't convince anyone he was actually sane.
52
In 52 week 41, Ralph Dibny confronts an emaciated Doctor Milo, who appears without his lower legs, and in a wheelchair, which is actually used to disguise the Silver Wheel of Nyorlath.
In other media
Batman: The Animated Series
Dr. Achilles Milo first appeared in the Batman: The Animated Series episode "Cat Scratch Fever" voiced by Treat Williams. He engineered a pandemic|plague to infect Gotham's stray pet population for Roland Daggett. This plague also affected Catwoman when her cat Isis attacked her.
Dr. Milo later reappeared in "Moon of the Wolf" where he was the one responsible for making an untraceable steroid/wolf hormone (when he got the Alaskan Timber Wolves from zookeeper John Hamner) derivative for an athlete named Anthony Romulus, which not only enhanced his athletic abilities, but also turned him into a living werewolf. Batman caught him, however, and sent him to prison.
Justice League Unlimited
Milo later resurfaced in Justice League Unlimited voiced by Armin Shimerman. He is seen as a member of Project Cadmus. Amanda Waller demoted him to a lower position after a failed warthog experiment in his research of Dr. Kirk Langstrom, the former Man-Bat. He then entered a room where Cadmus was holding Doomsday. After explaining his creation and his fight with Superman, Milo set Doomsday free to take revenge on Waller. However, Doomsday killed Milo offscreen upon release, telling him that his problems were over. Then, he went after Superman.